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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279003
Molecular formula	C21H24FNO4S
IUPAC name	4-[[benzenesulfonyl-[(4-fluorophenyl)methyl]amino]methyl]cyclohexane-1-carboxylic acid
Molecular weight	405.484
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.7
Synonyms	BDBM211101 DESXZXZGHZRVNQ-UHFFFAOYSA-N 4-((N-(4-fluorobenzyl)phenylsulfonamido)methyl)-cyclohexanecarboxylic acid CHEMBL3946036 US9247759, 5-22
Inchi Key	DESXZXZGHZRVNQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H24FNO4S/c22-19-12-8-17(9-13-19)15-23(28(26,27)20-4-2-1-3-5-20)14-16-6-10-18(11-7-16)21(24)25/h1-5,8-9,12-13,16,18H,6-7,10-11,14-15H2,(H,24,25)
PubChem CID	25205186
ChEMBL	CHEMBL3946036
IUPHAR	N/A
BindingDB	211101
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	240.0 nM	None	ChEMBL
IC50	240.0 nM	N/A	BindingDB

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