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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1278988
Molecular formula	C19H22FNO4S2
IUPAC name	4-[[(4-fluorophenyl)methyl-thiophen-2-ylsulfonylamino]methyl]cyclohexane-1-carboxylic acid
Molecular weight	411.506
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.7
Synonyms	US9247759, 5-51 CHEMBL3972175 BDBM211127
Inchi Key	BZJHTCNPHGTRNV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H22FNO4S2/c20-17-9-5-15(6-10-17)13-21(27(24,25)18-2-1-11-26-18)12-14-3-7-16(8-4-14)19(22)23/h1-2,5-6,9-11,14,16H,3-4,7-8,12-13H2,(H,22,23)
PubChem CID	57944958
ChEMBL	CHEMBL3972175
IUPHAR	N/A
BindingDB	211127
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	342.0 nM	None	ChEMBL
IC50	342.0 nM	N/A	BindingDB

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