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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279663
Molecular formula	C16H10N4O2S
IUPAC name	(E)-2-cyano-3-(furan-2-yl)-N-(5-phenyl-1,3,4-thiadiazol-2-yl)prop-2-enamide
Molecular weight	322.342
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.2
Synonyms	SCHEMBL1279667 ATZYSDQCRVRCEQ-FMIVXFBMSA-N CHEMBL3908011 (E)-2-cyano-3-(furan-2-yl)-N-(5-phenyl-1,3,4-thiadiazol-2-yl)acrylamide US9247759, 6-2 BDBM211218 [ Show all ]
Inchi Key	ATZYSDQCRVRCEQ-FMIVXFBMSA-N
Inchi ID	InChI=1S/C16H10N4O2S/c17-10-12(9-13-7-4-8-22-13)14(21)18-16-20-19-15(23-16)11-5-2-1-3-6-11/h1-9H,(H,18,20,21)/b12-9+
PubChem CID	57462263
ChEMBL	CHEMBL3908011
IUPHAR	N/A
BindingDB	211218
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	499.0 nM	N/A	BindingDB
IC50	499.0 nM	None	ChEMBL

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