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Name | 5-hydroxytryptamine receptor 2A |
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Species | Homo sapiens (Human) |
Gene | HTR2A |
Synonym | 5-HT-2 serotonin receptor 2A serotonin 5HT-2 receptor 5-HT-2A 5-HT2A receptor [ Show all ] |
Disease | Depression Unspecified Diabetes Erythropoietic porphyria Fibromyalgia [ Show all ] |
Length | 471 |
Amino acid sequence | MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV |
UniProt | P28223 |
Protein Data Bank | 6a93, 6a94 |
GPCR-HGmod model | P28223 |
3D structure model | This structure is from PDB ID 6a93. |
BioLiP | BL0441025,BL0441028, BL0441031, BL0441030,BL0441033, BL0441029,BL0441032, BL0441026, BL0441024,BL0441027 |
Therapeutic Target Database | T32060 |
ChEMBL | CHEMBL224 |
IUPHAR | 6 |
DrugBank | BE0000451 |
Name | CHEMBL220521 |
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Molecular formula | C12H13ClN2O2 |
IUPAC name | (10bR)-10-chloro-7-methoxy-2,3,4,10b-tetrahydro-1H-pyrazino[1,2-b]isoindol-6-one |
Molecular weight | 252.698 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 0.9 |
Synonyms | BDBM50205885 SCHEMBL13119133 ((R)-10-chloro-7-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2 H)-one |
Inchi Key | AGSBXAJKEQTLFT-QMMMGPOBSA-N |
Inchi ID | InChI=1S/C12H13ClN2O2/c1-17-9-3-2-7(13)10-8-6-14-4-5-15(8)12(16)11(9)10/h2-3,8,14H,4-6H2,1H3/t8-/m0/s1 |
PubChem CID | 16115390 |
ChEMBL | CHEMBL220521 |
IUPHAR | N/A |
BindingDB | 50205885 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Intrinsic activity | 1.0 - | PMID17315987 | ChEMBL |
Ki | <10000.0 nM | PMID17315987 | BindingDB,ChEMBL |
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