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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	N-formyl peptide receptor 2
Species	Homo sapiens (Human)
Gene	FPR2
Synonym	FPRH1 FPRH2 FPRL1 HM63 Lipoxin A4 receptor LXA4 receptor LXA4R FPR2A FPR2/ALX Fpr-rs2 ALX ALX/FPR2 ALXR FMLP-R-I FMLP-related receptor I FMLPX formyl peptide receptor 2 formyl peptide receptor, related sequence 2 Formyl peptide receptor-like 1 RFP [ Show all ]
Disease	N/A
Length	351
Amino acid sequence	METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
UniProt	P25090
Protein Data Bank	N/A
GPCR-HGmod model	P25090
3D structure model	This predicted structure model is from GPCR-EXP P25090.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4227
IUPHAR	223
DrugBank	N/A

Ligand

Name	SMR000022571
Molecular formula	C17H18N4O
IUPAC name	2-(4-methylpiperidin-1-yl)-6-oxo-4-phenyl-1H-pyrimidine-5-carbonitrile
Molecular weight	294.358
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.1
Synonyms	2-(4-methylpiperidin-1-yl)-4-oxo-6-phenyl-1H-pyrimidine-5-carbonitrile CHEMBL1387663 4-keto-2-(4-methylpiperidino)-6-phenyl-1H-pyrimidine-5-carbonitrile HMS2385C07 2-(4-methyl-1-piperidinyl)-4-oxo-6-phenyl-1H-pyrimidine-5-carbonitrile BDBM37708 SR-01000120573 cid_3239026 AC1MMHX4 MLS000044627 2-(4-methylpiperidin-1-yl)-4-oxidanylidene-6-phenyl-1H-pyrimidine-5-carbonitrile SR-01000120573-1 4-hydroxy-2-(4-methylpiperidin-1-yl)-6-phenylpyrimidine-5-carbonitrile EU-0089245 AKOS001773326 [ Show all ]
Inchi Key	CVHXUJXFNBZJLC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H18N4O/c1-12-7-9-21(10-8-12)17-19-15(13-5-3-2-4-6-13)14(11-18)16(22)20-17/h2-6,12H,7-10H2,1H3,(H,19,20,22)
PubChem CID	135497667
ChEMBL	CHEMBL1387663
IUPHAR	N/A
BindingDB	37708
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<66700.0 nM	N/A	BindingDB
Ki	<40300.0 nM	N/A	BindingDB

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