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GLASS

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GPCR

Name	Alpha-1D adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA1D
Synonym	alpha1a/d-adrenoceptor adrenergic receptor delta1 Gpcr8 Adrd1 ADRA1R ADRA1A ADRA1 Adra-1 alpha 1D-adrenoceptor alpha 1D-adrenoreceptor alpha1D-adrenoceptor alpha1A/D alpha1A-adrenoceptor Alpha-adrenergic receptor 1a Alpha-1D adrenoreceptor Alpha-1D adrenoceptor Alpha-1A adrenergic receptor alpha1D-AR [ Show all ]
Disease	Urinary incontinence Benign prostatic hyperplasia Congestive heart failure Diabetes Erectile dysfunction Fecal incontinence Glaucoma Hypertension Pediatric cancer Peripheral vascular disease Prostate disease Prostate hyperplasia [ Show all ]
Length	572
Amino acid sequence	MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI
UniProt	P25100
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T53381
ChEMBL	CHEMBL223
IUPHAR	24
DrugBank	BE0004863, BE0000715

Ligand

Name	levomedetomidine
Molecular formula	C13H16N2
IUPAC name	5-[(1R)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
Molecular weight	200.285
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	3.1
Synonyms	1H-Imidazole, 4-((1R)-1-(2,3-dimethylphenyl)ethyl)- AC1Q4WOC K66HW308K4 UNII-K66HW308K4 4-[(1R)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole CHEMBL397901 LS-78519 (R)-Medetomidine Dexmedetomidinum [INN-Latin] NCGC00241106-01 1H-Imidazole, 4-(1-(2,3-dimethylphenyl)ethyl)-, (R)- BDBM50241196 l-Medetomidine UNII-MR15E85MQM component CUHVIMMYOGQXCV-LLVKDONJSA-N (-)-Medetomidine 4-[(R)-1-(2,3-Dimethyl-phenyl)-ethyl]-1H-imidazole Dexmedetomidina [INN-Spanish] Medetomidine, (R)- 119717-21-4 AC1L1TL8 FT-0670775 SCHEMBL12092460 1H-Imidazole, 4-[(1R)-1-(2,3-dimethylphenyl)ethyl]- CHEBI:48555 ZINC4676236 (R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole 5-[(1R)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole Dexmedetomidine [USAN:INN:BAN] MPV 1441 [ Show all ]
Inchi Key	CUHVIMMYOGQXCV-LLVKDONJSA-N
Inchi ID	InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m1/s1
PubChem CID	60612
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50241196
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	79.4328 nM	PMID11082457	BindingDB

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