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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	levomedetomidine
Molecular formula	C13H16N2
IUPAC name	5-[(1R)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
Molecular weight	200.285
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	3.1
Synonyms	1H-Imidazole, 4-((1R)-1-(2,3-dimethylphenyl)ethyl)- AC1Q4WOC K66HW308K4 UNII-K66HW308K4 4-[(1R)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole CHEMBL397901 LS-78519 (R)-Medetomidine Dexmedetomidinum [INN-Latin] NCGC00241106-01 1H-Imidazole, 4-(1-(2,3-dimethylphenyl)ethyl)-, (R)- BDBM50241196 l-Medetomidine UNII-MR15E85MQM component CUHVIMMYOGQXCV-LLVKDONJSA-N (-)-Medetomidine 4-[(R)-1-(2,3-Dimethyl-phenyl)-ethyl]-1H-imidazole Dexmedetomidina [INN-Spanish] Medetomidine, (R)- 119717-21-4 AC1L1TL8 FT-0670775 SCHEMBL12092460 1H-Imidazole, 4-[(1R)-1-(2,3-dimethylphenyl)ethyl]- CHEBI:48555 ZINC4676236 (R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole 5-[(1R)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole Dexmedetomidine [USAN:INN:BAN] MPV 1441 [ Show all ]
Inchi Key	CUHVIMMYOGQXCV-LLVKDONJSA-N
Inchi ID	InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m1/s1
PubChem CID	60612
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50241196
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2.5119 nM	PMID11082457	BindingDB
Ki	15.1356 nM	PMID11082457	BindingDB
Ki	95.5 nM	PMID9605427	BindingDB

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