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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Alpha-1A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1a
Synonym	alpha1c alpha1A-adrenoceptor alpha1a Alpha-1C adrenergic receptor Alpha-1A adrenoreceptor Alpha-1A adrenoceptor alpha-1A adrenergic receptor ADRA1C alpha 1C-adrenergic receptor alpha 1A-adrenoreceptor alpha 1A-adrenoceptor adrenergic receptor, alpha 1a adrenergic receptor alpha 1c adrenergic alpha 1c receptor ADRA1L1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
UniProt	P43140
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL319
IUPHAR	22
DrugBank	N/A

Ligand

Name	levomedetomidine
Molecular formula	C13H16N2
IUPAC name	5-[(1R)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
Molecular weight	200.285
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	3.1
Synonyms	1H-Imidazole, 4-((1R)-1-(2,3-dimethylphenyl)ethyl)- AC1Q4WOC K66HW308K4 UNII-K66HW308K4 4-[(1R)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole CHEMBL397901 LS-78519 (R)-Medetomidine Dexmedetomidinum [INN-Latin] NCGC00241106-01 1H-Imidazole, 4-(1-(2,3-dimethylphenyl)ethyl)-, (R)- BDBM50241196 l-Medetomidine UNII-MR15E85MQM component CUHVIMMYOGQXCV-LLVKDONJSA-N (-)-Medetomidine 4-[(R)-1-(2,3-Dimethyl-phenyl)-ethyl]-1H-imidazole Dexmedetomidina [INN-Spanish] Medetomidine, (R)- 119717-21-4 AC1L1TL8 FT-0670775 SCHEMBL12092460 1H-Imidazole, 4-[(1R)-1-(2,3-dimethylphenyl)ethyl]- CHEBI:48555 ZINC4676236 (R)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole 5-[(1R)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole Dexmedetomidine [USAN:INN:BAN] MPV 1441 [ Show all ]
Inchi Key	CUHVIMMYOGQXCV-LLVKDONJSA-N
Inchi ID	InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m1/s1
PubChem CID	60612
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50241196
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	63.0957 nM	PMID11082457	BindingDB
Ki	316.228 nM	PMID11082457	BindingDB

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