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GPCR

NameC-C chemokine receptor type 2
SpeciesMus musculus (Mouse)
GeneCcr2
SynonymJE/FIC receptor
CKR2
chemokine receptor CCR2
chemokine (C-C motif) receptor 2
CD192
[ Show all ]
DiseaseN/A for non-human GPCRs
Length373
Amino acid sequenceMEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL
UniProtP51683
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5412
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3589847
Molecular formulaC31H31F5N2O2
IUPAC name2-(4-fluorophenyl)-N-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-4-spiro[3,4-dihydroisochromene-1,4'-piperidine]-1'-ylbutanamide
Molecular weight558.593
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP5.9
SynonymsBDBM50097893
Inchi KeyPPJHFLILDOHJMC-UHFFFAOYSA-N
Inchi IDInChI=1S/C31H31F5N2O2/c32-25-7-5-22(6-8-25)27(29(39)37-20-21-17-24(31(34,35)36)19-26(33)18-21)9-13-38-14-11-30(12-15-38)28-4-2-1-3-23(28)10-16-40-30/h1-8,17-19,27H,9-16,20H2,(H,37,39)
PubChem CID122181153
ChEMBLCHEMBL3589847
IUPHARN/A
BindingDB50097893
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC503630.0 nMPMID25766632BindingDB,ChEMBL

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