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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3629478
Molecular formula	C24H28ClN5O4
IUPAC name	tert-butyl 7-[6-(2-chloro-4-cyanoanilino)-5-methylpyrimidin-4-yl]oxy-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate
Molecular weight	485.969
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	4.3
Synonyms	BDBM50128506
Inchi Key	KVLGFMVRLPXNIB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H28ClN5O4/c1-14-21(29-20-6-5-15(10-26)7-19(20)25)27-13-28-22(14)33-18-8-16-11-32-12-17(9-18)30(16)23(31)34-24(2,3)4/h5-7,13,16-18H,8-9,11-12H2,1-4H3,(H,27,28,29)
PubChem CID	122194337
ChEMBL	CHEMBL3629478
IUPHAR	N/A
BindingDB	50128506
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
%max	38.0 %	PMID26433449	ChEMBL
%max	54.0 %	PMID26433449	ChEMBL
EC50	17.0 nM	PMID26433449	BindingDB,ChEMBL
EC50	114.0 nM	PMID26433449	BindingDB,ChEMBL

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