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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL1771093
Molecular formula	C20H24ClN7
IUPAC name	4-[4-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]piperidin-1-yl]-6-methylpyrimidine-2-carbonitrile
Molecular weight	397.911
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	3.7
Synonyms	BDBM50342692 SCHEMBL3622584 4-(1''-(5-chloropyrimidin-2-yl)-4,4''-bipiperidin-1-yl)-6-methylpyrimidine-2-carbonitrile
Inchi Key	CQVIOYGVYWJQDB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H24ClN7/c1-14-10-19(26-18(11-22)25-14)27-6-2-15(3-7-27)16-4-8-28(9-5-16)20-23-12-17(21)13-24-20/h10,12-13,15-16H,2-9H2,1H3
PubChem CID	25012524
ChEMBL	CHEMBL1771093
IUPHAR	N/A
BindingDB	50342692
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2.0 nM	PMID21273063	BindingDB,ChEMBL

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