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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3629598
Molecular formula	C22H24ClN5O4S
IUPAC name	3-chloro-4-[[6-[(9-cyclopropylsulfonyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)oxy]-5-methylpyrimidin-4-yl]amino]benzonitrile
Molecular weight	489.975
Hydrogen bond acceptor	9
Hydrogen bond donor	1
XlogP	3.2
Synonyms	BDBM50128505
Inchi Key	JWHKXNLBDHGTSF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H24ClN5O4S/c1-13-21(27-20-5-2-14(9-24)6-19(20)23)25-12-26-22(13)32-17-7-15-10-31-11-16(8-17)28(15)33(29,30)18-3-4-18/h2,5-6,12,15-18H,3-4,7-8,10-11H2,1H3,(H,25,26,27)
PubChem CID	122194421
ChEMBL	CHEMBL3629598
IUPHAR	N/A
BindingDB	50128505
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
%max	64.0 %	PMID26433449	ChEMBL
EC50	268.0 nM	PMID26433449	BindingDB,ChEMBL

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