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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3629596
Molecular formula	C23H24ClN5O4
IUPAC name	(1-methylcyclopropyl) 9-[6-(2-chloro-4-cyanoanilino)pyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Molecular weight	469.926
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	3.4
Synonyms	BDBM50128501 SCHEMBL10120674
Inchi Key	JLJVLLNZCMNSLJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H24ClN5O4/c1-23(4-5-23)33-22(30)29-9-15-11-31-12-16(10-29)21(15)32-20-7-19(26-13-27-20)28-18-3-2-14(8-25)6-17(18)24/h2-3,6-7,13,15-16,21H,4-5,9-12H2,1H3,(H,26,27,28)
PubChem CID	68040046
ChEMBL	CHEMBL3629596
IUPHAR	N/A
BindingDB	50128501
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
%max	88.0 %	PMID26433449	ChEMBL
EC50	25.0 nM	PMID26433449	BindingDB,ChEMBL

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