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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Cysteinyl leukotriene receptor 2
Species	Homo sapiens (Human)
Gene	CYSLTR2
Synonym	CysLTR2 CysLT2 receptor LTC4 HPN321 hGPCR21 HG57 G-protein coupled receptor HG57 CYSLT2R G-protein coupled receptor GPCR21 [ Show all ]
Disease	Unspecified Asthma
Length	346
Amino acid sequence	MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
UniProt	Q9NS75
Protein Data Bank	N/A
GPCR-HGmod model	Q9NS75
3D structure model	This predicted structure model is from GPCR-EXP Q9NS75.
BioLiP	N/A
Therapeutic Target Database	T74238
ChEMBL	CHEMBL4330
IUPHAR	270
DrugBank	BE0000099

Ligand

Name	CHEMBL3597622
Molecular formula	C34H34ClNO5
IUPAC name	4-[3-(carboxymethyl)-7-[2-[4-[4-(3-chloro-2-methylphenyl)butoxy]phenyl]ethynyl]-2-methylindol-1-yl]butanoic acid
Molecular weight	572.098
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	7.3
Synonyms	BDBM50104909
Inchi Key	IYOMUMGOCXYDNW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C34H34ClNO5/c1-23-26(9-6-12-31(23)35)8-3-4-21-41-28-18-15-25(16-19-28)14-17-27-10-5-11-29-30(22-33(39)40)24(2)36(34(27)29)20-7-13-32(37)38/h5-6,9-12,15-16,18-19H,3-4,7-8,13,20-22H2,1-2H3,(H,37,38)(H,39,40)
PubChem CID	122183757
ChEMBL	CHEMBL3597622
IUPHAR	N/A
BindingDB	50104909
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	55.0 nM	PMID26200813	BindingDB,ChEMBL

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