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GLASS

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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	3-Methyltoxoflavin
Molecular formula	C8H9N5O2
IUPAC name	1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione
Molecular weight	207.193
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	-0.7
Synonyms	1,3,6-trimethyl-6-hydropyrimidino[5,4-e]1,2,4-triazine-5,7-dione AC1LA2XZ CPXHNWKHOFNPDO-UHFFFAOYSA-N MCULE-2510138695 SMR000121073 1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-quinone BRD-K80622725-001-10-2 GNF-Pf-2272 NCGC00093522-01 SR-01000322764-3 32502-62-8 CHEMBL601757 KSC-1-228 Pyrimido[5,4-E][1,2,4]triazine-5,7(1H,6H)-dione, 1,3,6-trimethyl- US9073941, 611 1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione BAS 00444306 CS-0034261 methyltoxoflavin SR-01000322764 3-methyl toxoflavin CHEBI:95315 HMS2304H14 NCGC00093522-02 ST50002651 1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione cid_460747 KUC104460N SCHEMBL2180986 1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione BDBM34671 D0P0CM MLS000528498 SR-01000322764-1 HY-111117 Pyrimido(5,4-e)-1,2,4-triazine-5,7-(1H,6H)-dione, 1,3,6-trmethyl- STK397047 [ Show all ]
Inchi Key	CPXHNWKHOFNPDO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H9N5O2/c1-4-9-5-6(13(3)11-4)10-8(15)12(2)7(5)14/h1-3H3
PubChem CID	460747
ChEMBL	CHEMBL601757
IUPHAR	N/A
BindingDB	34671
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	11220.2 nM	PubChem BioAssay data set	ChEMBL

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