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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	G-protein coupled receptor family C group 6 member A
Species	Mus musculus (Mouse)
Gene	Gprc6a
Synonym	G protein-coupled receptor G protein-coupled receptor, class C, group 6, member A G protein-coupled receptor, family C, group 6, member A GPCR6A GPRC6 receptor
Disease	N/A for non-human GPCRs
Length	928
Amino acid sequence	MALLITVVTCFMIILDTSQSCHTPDDFVAITSPGHIMIGGLFAIHEKMLSSDDHPRRPQIQKCAGFEISVFLQTLAMIHSIEMINNSTLLSGVKLGYEIYDTCTEVTAAMAATLRFLSKFNCSRETVVFQCDYSSYMPRVKAVIGAGYSETSIAVSRMLNLQLMPQVSYESTAEILSDKIRFPSFLRTVPSDFYQTKAMAHLIRQSGWNWIGAITTDDDYGRLALNTFAIQAAENNVCIAFKEVLPAFLSDNTIEVRINQTLEKIIAEAQVNVIVVFLRKFHVFNLFTKAIERKISKIWIASDNWSTATKIITIPNVKKLGKVVGFAFRRGNTSSFHSFLQTLHMYPNDNNKPLHEFAMLVSACKYIKDGDLSQCISNYSQATLTYDTTKTIENHLFKRNDFLWHYTEPGLIYSIQLAVFALGHAIRDLCQARDCKKPNAFQPWELLAVLKNVTFTDGRNSFHFDAHGDLNTGYDVVLWKETNGLMTVTKMAEYDLQRDVFITTNQETKHEFRKLKQILSKCSKECSPGQMKKATGSQHSCCYECVSCPENHYSNETDMDHCLLCNNETHWAPVRSTTCFEKEVEYLDWDDSLALLLIALSLLGIAFVLAIGIIFTRNLKTPVVKSSGGLVVCYVMLICHALNFASTGFFIGEPQDFACKTRQTLFGVSFTLCVSCILTKSLKILLAFSFDPKLTMFLKCLYRPVPIVLTCTGIQVVICTLWLVLAAPSVEENISLPRVIILECEEGSALAFGTMLGYITVLAFICFVFAFKGRKLPENYNEAKFLTFGMLIYFIAWITFIPVYTTTFGKYLPAVEIIVILISNYGILCCIFFPKCYIILCKQKTNTKSAFLQMVYNYSAHSVDSLALSHVSLDSTSYDTATTNQSPGNKMTACQNDNHLPAQVLPHTGTAKTIKASKTLRQKRSSSI
UniProt	Q8K4Z6
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3347255
IUPHAR	55
DrugBank	N/A

Ligand

Name	CHEMBL3633650
Molecular formula	C23H25N3O3
IUPAC name	2-[methyl-(2-morpholin-4-yl-2-oxoethyl)amino]-1-(2-phenyl-1H-indol-3-yl)ethanone
Molecular weight	391.471
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.6
Synonyms	AKOS027324569 2-[methyl-(2-morpholin-4-yl-2-oxoethyl)amino]-1-(2-phenyl-1H-indol-3-yl)ethanone 950034-18-1 ZINC57473783 BDBM50133676 2-{methyl[2-(morpholin-4-yl)-2-oxoethyl]amino}-1-(2-phenyl-1H-indol-3-yl)ethan-1-one MolPort-005-659-662 AC1PJFPF Z90240217 [ Show all ]
Inchi Key	FRUZIJBUVKTDFU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H25N3O3/c1-25(16-21(28)26-11-13-29-14-12-26)15-20(27)22-18-9-5-6-10-19(18)24-23(22)17-7-3-2-4-8-17/h2-10,24H,11-16H2,1H3
PubChem CID	9044803
ChEMBL	CHEMBL3633650
IUPHAR	N/A
BindingDB	50133676
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	21877.6 nM	PMID26516782	ChEMBL
IC50	21878.0 nM	PMID26516782	BindingDB
IC50	21900.0 nM	PMID26516782	BindingDB,ChEMBL

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