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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Parathyroid hormone/parathyroid hormone-related peptide receptor
Species	Homo sapiens (Human)
Gene	PTH1R
Synonym	PTH1 receptor PTHR PTH/PTHrP type I receptor PTH/PTHr receptor PPR Parathyroid hormone 1 receptor PTHR1 [ Show all ]
Disease	N/A
Length	593
Amino acid sequence	MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
UniProt	Q03431
Protein Data Bank	6fj3, 3h3g, 3c4m
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 6fj3.
BioLiP	BL0161387, BL0433539,BL0433540, BL0161388, BL0143680,BL0143682, BL0143681,BL0143683
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1793
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	(4,6-diphenylpyrimidin-2-yl)hydrazine
Molecular formula	C16H14N4
IUPAC name	(4,6-diphenylpyrimidin-2-yl)hydrazine
Molecular weight	262.316
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.1
Synonyms	5588-58-9 CHEMBL1375248 MLS000856324 AKOS001016733 DTXSID40367886 SMR000279269 (4,6-Diphenyl-pyrimidin-2-yl)-hydrazine 2-HYDRAZINO-4,6-DIPHENYL-PYRIMIDINE CBDivE_006945 HMS2686O04 cid_2303647 MolPort-001-915-228 BAS 00117023 Enamine_000322 ZINC3091431 (4,6-diphenylpyrimidin-2-yl)diazane 4,6-diphenylpyrimidin-2-ylhydrazine MCULE-8342616212 AC1M49QR CTK7F1728 SCHEMBL2401750 (4,6-diphenyl-2-pyrimidinyl)hydrazine BDBM67270 HMS1394O14 [ Show all ]
Inchi Key	DBYCDKBEVKWZNL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H14N4/c17-20-16-18-14(12-7-3-1-4-8-12)11-15(19-16)13-9-5-2-6-10-13/h1-11H,17H2,(H,18,19,20)
PubChem CID	2303647
ChEMBL	CHEMBL1375248
IUPHAR	N/A
BindingDB	67270
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	50118.7 nM	PubChem BioAssay data set	ChEMBL

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