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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	1-[(2-chloro-1,3-thiazol-5-yl)methyl]-4-phenylpiperazine
Molecular formula	C14H16ClN3S
IUPAC name	2-chloro-5-[(4-phenylpiperazin-1-yl)methyl]-1,3-thiazole
Molecular weight	293.813
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.4
Synonyms	9P-927 KS-00003GFA Bionet2_000634 MolPort-002-883-444 2-chloro-5-[(4-phenylpiperazin-1-yl)methyl]-1,3-thiazole HMS1365M18 ZINC20405793 AC1LSJS0 MCULE-9283624051 Oprea1_559185 478248-87-2 HMS2672M18 AKOS015993799 MLS000721352 CHEMBL1487540 SMR000335424 [ Show all ]
Inchi Key	CZPHEYMHFHOUKP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H16ClN3S/c15-14-16-10-13(19-14)11-17-6-8-18(9-7-17)12-4-2-1-3-5-12/h1-5,10H,6-9,11H2
PubChem CID	1489112
ChEMBL	CHEMBL1487540
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	501.2 nM	PubChem BioAssay data set	ChEMBL

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