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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Parathyroid hormone/parathyroid hormone-related peptide receptor
Species	Homo sapiens (Human)
Gene	PTH1R
Synonym	PTH1 receptor PTHR PTH/PTHrP type I receptor PTH/PTHr receptor PPR Parathyroid hormone 1 receptor PTHR1 [ Show all ]
Disease	N/A
Length	593
Amino acid sequence	MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
UniProt	Q03431
Protein Data Bank	6fj3, 3h3g, 3c4m
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 6fj3.
BioLiP	BL0161387, BL0433539,BL0433540, BL0161388, BL0143680,BL0143682, BL0143681,BL0143683
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1793
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	6-(4-methylpiperazin-1-yl)-9H-purine
Molecular formula	C10H14N6
IUPAC name	6-(4-methylpiperazin-1-yl)-7H-purine
Molecular weight	218.264
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	0.5
Synonyms	AB00588487-02 D0QT2F NSC-510935 ST45178781 6-(4-methylpiperazin-1-yl)-7H-purine AKOS005562847 HMS2684L19 SCHEMBL13718480 ZINC213869 6-(4-methylpiperazinyl)purine MolPort-000-384-358 SR-01000104630 AC1LFNRL F0578-0118 NSC510935 STK630143 BDBM50304512 MCULE-5386395090 SDCCGMLS-0065440.P001 99172-01-7 CHEMBL594152 MolPort-000-847-583 SR-01000104630-1 AKOS001427557 HMS1650E09 Oprea1_666011 Z57745256 6-(4-methylpiperazin-1-yl)-9Hpurine CCG-26902 MLS000419169 SMR000319851 [ Show all ]
Inchi Key	AXPCNBLIEMWMMG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H14N6/c1-15-2-4-16(5-3-15)10-8-9(12-6-11-8)13-7-14-10/h6-7H,2-5H2,1H3,(H,11,12,13,14)
PubChem CID	756701
ChEMBL	CHEMBL594152
IUPHAR	N/A
BindingDB	50304512
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	89125.1 nM	PubChem BioAssay data set	ChEMBL

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