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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Homo sapiens (Human)
Gene	HTR6
Synonym	5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 5-HT6 [ Show all ]
Disease	Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis Cognitive disorders Unspecified Anxiety disorder Alzheimer disease; Dementia Alzheimer disease; Anxiety disorder Alzheimer disease [ Show all ]
Length	440
Amino acid sequence	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProt	P50406
Protein Data Bank	N/A
GPCR-HGmod model	P50406
3D structure model	This predicted structure model is from GPCR-EXP P50406.
BioLiP	N/A
Therapeutic Target Database	T16691
ChEMBL	CHEMBL3371
IUPHAR	11
DrugBank	BE0000945

Ligand

Name	CHEMBL3696970
Molecular formula	C20H21NO5S
IUPAC name	1-[[8-(benzenesulfonyl)-1,2,3,4-tetrahydro-[1]benzofuro[3,2-c]pyridin-6-yl]oxy]propan-2-ol
Molecular weight	387.45
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	2.3
Synonyms	US9067949, 219 BDBM166362 SCHEMBL10345200
Inchi Key	AHXOZVYYRPXHSG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H21NO5S/c1-13(22)12-25-19-10-15(27(23,24)14-5-3-2-4-6-14)9-16-17-11-21-8-7-18(17)26-20(16)19/h2-6,9-10,13,21-22H,7-8,11-12H2,1H3
PubChem CID	68115874
ChEMBL	CHEMBL3696970
IUPHAR	N/A
BindingDB	166362
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7.7 nM	, None	BindingDB,ChEMBL

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