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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	C-C chemokine receptor-like 2
Species	Homo sapiens (Human)
Gene	CCRL2
Synonym	ACR5 CRAM-B CRAM-A CKRX Chemokine receptor X Chemokine receptor CCR11 CCRL2 CCR6 CCR11 Putative MCP-1 chemokine receptor [ Show all ]
Disease	N/A
Length	344
Amino acid sequence	MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV
UniProt	O00421
Protein Data Bank	N/A
GPCR-HGmod model	O00421
3D structure model	This predicted structure model is from GPCR-EXP O00421.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2321627
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL2315927
Molecular formula	C26H29F3N6O3
IUPAC name	N-[1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Molecular weight	530.552
Hydrogen bond acceptor	11
Hydrogen bond donor	3
XlogP	3.1
Synonyms	MFANEEYLZLZCGQ-UHFFFAOYSA-N BDBM163449 US9062048, 76 N-(1-(4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl)azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide BDBM50425700 CHEMBL3704093 SCHEMBL9999075 [ Show all ]
Inchi Key	MFANEEYLZLZCGQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H29F3N6O3/c1-38-23-5-3-17(11-30-23)25(37)8-6-19(7-9-25)35-13-18(14-35)34-22(36)12-31-24-20-10-16(26(27,28)29)2-4-21(20)32-15-33-24/h2-5,10-11,15,18-19,37H,6-9,12-14H2,1H3,(H,34,36)(H,31,32,33)
PubChem CID	68004011
ChEMBL	CHEMBL3704093
IUPHAR	N/A
BindingDB	163449
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	19.0 nM	, None	BindingDB,ChEMBL

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