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GPCR

NameC-C chemokine receptor-like 2
SpeciesHomo sapiens (Human)
GeneCCRL2
SynonymACR5
CRAM-B
CRAM-A
CKRX
Chemokine receptor X
[ Show all ]
DiseaseN/A
Length344
Amino acid sequenceMANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV
UniProtO00421
Protein Data BankN/A
GPCR-HGmod modelO00421
3D structure modelThis predicted structure model is from GPCR-EXP O00421.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2321627
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL9999211
Molecular formulaC21H26F3N5O
IUPAC nameN-[1-(4-methylcyclohexyl)azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Molecular weight421.468
Hydrogen bond acceptor8
Hydrogen bond donor2
XlogP4.0
SynonymsCHEMBL3704127
CGNXRMVSZDOGKE-UHFFFAOYSA-N
N-(1-(4-methylcyclohexyl)azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide
US9062048, 119
SCHEMBL15214710
[ Show all ]
Inchi KeyCGNXRMVSZDOGKE-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H26F3N5O/c1-13-2-5-16(6-3-13)29-10-15(11-29)28-19(30)9-25-20-17-8-14(21(22,23)24)4-7-18(17)26-12-27-20/h4,7-8,12-13,15-16H,2-3,5-6,9-11H2,1H3,(H,28,30)(H,25,26,27)
PubChem CID68004063
ChEMBLCHEMBL3704127
IUPHARN/A
BindingDB163492
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5082.0 nM, NoneBindingDB,ChEMBL

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