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GPCR

NameMas-related G-protein coupled receptor member X1
SpeciesMus musculus (Mouse)
GeneMrgprx1
SynonymMas-related G-protein coupled receptor member C11
Sensory neuron-specific G-protein coupled receptor 1
DiseaseN/A for non-human GPCRs
Length322
Amino acid sequenceMDPTISSHDTESTPLNETGHPNCTPILTLSFLVLITTLVGLAGNTIVLWLLGFRMRRKAISVYILNLALADSFFLCCHFIDSLLRIIDFYGLYAHKLSKDILGNAAIIPYISGLSILSAISTERCLCVLWPIWYHCHRPRNMSAIICALIWVLSFLMGILDWFSGFLGETHHHLWKNVDFIITAFLIFLFMLLSGSSLALLLRILCGPRRKPLSRLYVTIALTVMVYLICGLPLGLYLFLLYWFGVHLHYPFCHIYQVTAVLSCVNSSANPIIYFLVGSFRQHRKHRSLKRVLKRALEDTPEEDEYTDSHLHKTTEISESRY
UniProtQ8CIP3
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3341576
IUPHARN/A
DrugBankN/A

Ligand

NameRF 9
Molecular formulaC26H38N6O3
IUPAC nameN-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]adamantane-1-carboxamide
Molecular weight482.629
Hydrogen bond acceptor4
Hydrogen bond donor5
XlogP1.4
SynonymsSCHEMBL18041259
Adamantane-1-carboxylic acid [(S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-4-guanidino-butyl]-amide
D08UWO
1-adamantanecarbonyl-Arg-Phe-NH2
BDBM50336912
[ Show all ]
Inchi KeyUMKHUSRDQFQHAK-RNJMTYCLSA-N
Inchi IDInChI=1S/C26H38N6O3/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t17?,18?,19?,20-,21-,26?/m0/s1
PubChem CID53320361
ChEMBLCHEMBL1672380
IUPHAR1486
BindingDB50336912
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50316.23 nMPMID25288495ChEMBL

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