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GPCR

NameAlpha-1B adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdra1b
Synonymadrenergic receptor
alpha 1B-adrenoceptor
alpha 1B-adrenoreceptor
adrenergic alpha 1B receptor
Alpha-1B adrenoceptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length515
Amino acid sequenceMNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGTQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESPGTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF
UniProtP15823
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL315
IUPHAR23
DrugBankN/A

Ligand

NameCHEMBL3415016
Molecular formulaC23H27N5O4
IUPAC nameN-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]-7-nitro-1H-indole-2-carboxamide
Molecular weight437.5
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP3.4
SynonymsN-[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]-7-nitro-1H-indole-2-carboxamide
J3.555.756C
Inchi KeyFKSSSJHSNYWMJK-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H27N5O4/c1-32-21-9-3-2-7-19(21)27-14-12-26(13-15-27)11-5-10-24-23(29)18-16-17-6-4-8-20(28(30)31)22(17)25-18/h2-4,6-9,16,25H,5,10-15H2,1H3,(H,24,29)
PubChem CID73437730
ChEMBLCHEMBL3415016
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Kd645.65 nMPMID25874333ChEMBL

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