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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	CHEMBL3358450
Molecular formula	C25H35N5O3S
IUPAC name	3-(diethylamino)-N-[(1R)-1-[3-(4-methoxyphenyl)-1H-1,2,4-triazol-5-yl]-3-phenylpropyl]propane-1-sulfonamide
Molecular weight	485.647
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	4.0
Synonyms	SCHEMBL1990385 BDBM50051783 EX-1350
Inchi Key	AYQAIVDVNTXQCJ-HSZRJFAPSA-N
Inchi ID	InChI=1S/C25H35N5O3S/c1-4-30(5-2)18-9-19-34(31,32)29-23(17-12-20-10-7-6-8-11-20)25-26-24(27-28-25)21-13-15-22(33-3)16-14-21/h6-8,10-11,13-16,23,29H,4-5,9,12,17-19H2,1-3H3,(H,26,27,28)/t23-/m1/s1
PubChem CID	25032438
ChEMBL	CHEMBL3358450
IUPHAR	N/A
BindingDB	50051783
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	15.0 nM	PMID25036503	BindingDB,ChEMBL

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