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GPCR

NameSomatostatin receptor type 2
SpeciesHomo sapiens (Human)
GeneSSTR2
Synonymsomatotropin release-inhibiting factor receptor
SRIF-1
SS-2-R
SS2-R
SS2R
[ Show all ]
DiseaseAcromegaly
Lung cancer
Neuroendocrine cancer
Length369
Amino acid sequenceMDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
UniProtP30874
Protein Data BankN/A
GPCR-HGmod modelP30874
3D structure modelThis predicted structure model is from GPCR-EXP P30874.
BioLiPN/A
Therapeutic Target DatabaseT53024
ChEMBLCHEMBL1804
IUPHAR356
DrugBankBE0003528

Ligand

NameCHEMBL3349676
Molecular formulaC58H70N12O8S2
IUPAC name(4R,7S,10S,13R,16S,19S)-10-(4-aminobutyl)-N-[(2S)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]-19-[[(2S)-2-amino-3-phenylpropanoyl]amino]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-16-(pyridin-3-ylmethyl)-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
Molecular weight1127.39
Hydrogen bond acceptor13
Hydrogen bond donor11
XlogP4.0
SynonymsN/A
Inchi KeyAXVKTGVAIQSFOE-WUIGHQTRSA-N
Inchi IDInChI=1S/C58H70N12O8S2/c1-34(2)50-58(78)69-49(56(76)65-45(51(61)71)27-36-21-22-38-16-6-7-17-39(38)25-36)33-80-79-32-48(68-52(72)42(60)26-35-13-4-3-5-14-35)57(77)66-46(28-37-15-12-24-62-30-37)54(74)67-47(29-40-31-63-43-19-9-8-18-41(40)43)55(75)64-44(53(73)70-50)20-10-11-23-59/h3-9,12-19,21-22,24-25,30-31,34,42,44-50,63H,10-11,20,23,26-29,32-33,59-60H2,1-2H3,(H2,61,71)(H,64,75)(H,65,76)(H,66,77)(H,67,74)(H,68,72)(H,69,78)(H,70,73)/t42-,44-,45-,46-,47+,48+,49-,50-/m0/s1
PubChem CID10772578
ChEMBLCHEMBL3349676
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC50123.0 nMPMID9544214ChEMBL

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