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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanocortin receptor 4
Species	Homo sapiens (Human)
Gene	MC4R
Synonym	MC4-R MC4 receptor
Disease	Obesity; Sexual dysfunction Obesity; Diabetes Obesity Metabolic disorders Sexual dysfunction Sexual dysfunction; Obesity Female sexual dysfunction Erectile dysfunction Cachexia Anorexia nervosa cachexia [ Show all ]
Length	332
Amino acid sequence	MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
UniProt	P32245
Protein Data Bank	N/A
GPCR-HGmod model	P32245
3D structure model	This predicted structure model is from GPCR-EXP P32245.
BioLiP	N/A
Therapeutic Target Database	T72458
ChEMBL	CHEMBL259
IUPHAR	285
DrugBank	N/A

Ligand

Name	CHEMBL385561
Molecular formula	C47H59N13O7
IUPAC name	(2S,5R,8S,16S)-16-acetamido-N-[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-7-[4-(diaminomethylideneamino)butyl]-2-(1H-imidazol-5-ylmethyl)-5-(naphthalen-2-ylmethyl)-3,6,13,17-tetraoxo-1,4,7,12-tetrazacycloheptadecane-8-carboxamide
Molecular weight	918.073
Hydrogen bond acceptor	9
Hydrogen bond donor	10
XlogP	0.9
Synonyms	Ac-c[Glu-His-D-Nal(2)''-N-alpha-guanidinylbutyl-Orn]-Trp-NH2 BDBM50200357
Inchi Key	AULGFKPDQPFEDA-SCVWNAOWSA-N
Inchi ID	InChI=1S/C47H59N13O7/c1-28(61)56-36-16-17-41(62)52-19-8-13-40(45(66)57-37(42(48)63)23-32-25-54-35-12-5-4-11-34(32)35)60(20-7-6-18-53-47(49)50)46(67)39(22-29-14-15-30-9-2-3-10-31(30)21-29)59-44(65)38(58-43(36)64)24-33-26-51-27-55-33/h2-5,9-12,14-15,21,25-27,36-40,54H,6-8,13,16-20,22-24H2,1H3,(H2,48,63)(H,51,55)(H,52,62)(H,56,61)(H,57,66)(H,58,64)(H,59,65)(H4,49,50,53)/t36-,37-,38-,39+,40-/m0/s1
PubChem CID	44417402
ChEMBL	CHEMBL385561
IUPHAR	N/A
BindingDB	50200357
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Activity	0.0 %	PMID17154518	ChEMBL

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