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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Pyroglutamylated RF-amide peptide receptor
Species	Homo sapiens (Human)
Gene	QRFPR
Synonym	QRFP receptor peptide p518 receptor Orexigenic neuropeptide QRFP receptor GPR103 G-protein coupled receptor 103 G protein-coupled receptor 103 AQ27 SP9155 [ Show all ]
Disease	N/A
Length	431
Amino acid sequence	MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
UniProt	Q96P65
Protein Data Bank	N/A
GPCR-HGmod model	Q96P65
3D structure model	This predicted structure model is from GPCR-EXP Q96P65.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5852
IUPHAR	333
DrugBank	N/A

Ligand

Name	CHEMBL3314357
Molecular formula	C27H28N4O
IUPAC name	[6-[(dimethylamino)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-(1-methyl-5-phenylpyrrolo[2,3-c]pyridin-2-yl)methanone
Molecular weight	424.548
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.8
Synonyms	BDBM50045839
Inchi Key	AOOWUKRCTFDBNJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H28N4O/c1-29(2)17-19-9-10-22-18-31(12-11-21(22)13-19)27(32)25-15-23-14-24(20-7-5-4-6-8-20)28-16-26(23)30(25)3/h4-10,13-16H,11-12,17-18H2,1-3H3
PubChem CID	118707558
ChEMBL	CHEMBL3314357
IUPHAR	N/A
BindingDB	50045839
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<41000.0 nM	PMID24937104	BindingDB,ChEMBL

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