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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Adenosine receptor A2b
Species	Homo sapiens (Human)
Gene	ADORA2B
Synonym	adenosine receptor A2b A2BR A2B receptor A2b
Disease	Paroxysmal supraventricular tachycardia Non-insulin dependent diabetes Hypertension Herpes simplex virus infection Apnea Asthma [ Show all ]
Length	332
Amino acid sequence	MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
UniProt	P29275
Protein Data Bank	N/A
GPCR-HGmod model	P29275
3D structure model	This predicted structure model is from GPCR-EXP P29275.
BioLiP	N/A
Therapeutic Target Database	T86679
ChEMBL	CHEMBL255
IUPHAR	20
DrugBank	BE0000241

Ligand

Name	CID 118733042
Molecular formula	C10H8N4OS
IUPAC name	5-methyl-2-pyrrol-1-yl-6H-[1,3]thiazolo[5,4-d]pyrimidin-7-one
Molecular weight	232.261
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	1.1
Synonyms	N/A
Inchi Key	ACLCHBCQJQXFJQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H8N4OS/c1-6-11-8(15)7-9(12-6)16-10(13-7)14-4-2-3-5-14/h2-5H,1H3,(H,11,12,15)
PubChem CID	118733042
ChEMBL	CHEMBL3415040
IUPHAR	N/A
BindingDB	50079887
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	3.0 %	PMID25874336	ChEMBL

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