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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Canis lupus familiaris (Dog)
Gene	HTR2A
Synonym	5-HT-2 5-HT-2A 5-hydroxytryptamine receptor Serotonin receptor 2A
Disease	N/A for non-human GPCRs
Length	470
Amino acid sequence	MDVLFEDNAPLSPTTSSLMPSNGDPRLYGNDLNAGDANTSDAFNWTVDAENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDIIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKKDAKSTDNDYSMVALGKQHSEDAPTDNINTVNEKVSCV
UniProt	O46635
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5781
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL492301
Molecular formula	C21H25ClN2O3S
IUPAC name	7-[4-(2-chlorophenoxy)piperidin-1-yl]sulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine
Molecular weight	420.952
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.8
Synonyms	7-(4-(2-chlorophenoxy)piperidin-1-ylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine BDBM50257621
Inchi Key	ZVFFUTQAERXNNF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H25ClN2O3S/c22-20-3-1-2-4-21(20)27-18-9-13-24(14-10-18)28(25,26)19-6-5-16-7-11-23-12-8-17(16)15-19/h1-6,15,18,23H,7-14H2
PubChem CID	44225654
ChEMBL	CHEMBL492301
IUPHAR	N/A
BindingDB	50257621
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	>10.0 %	PMID19269173	ChEMBL

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