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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL1951018
Molecular formula	C19H23FN4O4
IUPAC name	propan-2-yl 4-[6-(5-fluoropyridin-3-yl)oxy-5-methylpyrimidin-4-yl]oxypiperidine-1-carboxylate
Molecular weight	390.415
Hydrogen bond acceptor	8
Hydrogen bond donor	0
XlogP	3.0
Synonyms	BDBM50364549 ZINC73281014
Inchi Key	ZUWGPGNNDQQCAD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H23FN4O4/c1-12(2)26-19(25)24-6-4-15(5-7-24)27-17-13(3)18(23-11-22-17)28-16-8-14(20)9-21-10-16/h8-12,15H,4-7H2,1-3H3
PubChem CID	57397675
ChEMBL	CHEMBL1951018
IUPHAR	N/A
BindingDB	50364549
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	210.0 nM	PMID22264481	BindingDB,ChEMBL
Intrinsic activity	22.0 %	PMID22264481	ChEMBL

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