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GPCR

Name	Thromboxane A2 receptor
Species	Mus musculus (Mouse)
Gene	Tbxa2r
Synonym	Prostanoid TP receptor TP receptor TXA2-R
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MWPNGTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAIVASQHAALLDWRATDPSCRLCYFMGVAMVFFGLCPLLLGAAMASERFVGITRPFSRPTATSRRAWATVGLVWVAAGALGLLPLLGLGRYSVQYPGSWCFLTLGTQRGDVVFGLIFALLGSASVGLSLLLNTVSVATLCRVYHTREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFIMQTLLQTPPVMSFSGQLLRATEHQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFSSQLQAVSLRRPPAQAMLSGP
UniProt	P30987
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1795181
IUPHAR	346
DrugBank	N/A

Ligand

Name	arachidonic acid
Molecular formula	C20H32O2
IUPAC name	(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid
Molecular weight	304.474
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	6.3
Synonyms	(5Z,8Z,11Z,14Z)-5,8,11,14-Icosatetraenoic acid # Arachidonic acid, from non-animal source, >=98.5% (GC) 1753-EP2277858A1 BML3-B03 1753-EP2311830A1 CHEBI:15843 5,8,11,14-all-cis-Eicosatetraenoic acid CS-0032762 5-cis,8-cis,11-cis,14-cis-Eicosatetraenoic acid GTPL2391 789-EP2280008A2 Immunocytophyte 789-EP2301538A1 NCGC00094608-04 789-EP2311455A1 SR-01000838311-2 ACD ARACHIDONIC ACID (20:4 n-6) Arachidonic Acid, >90% Technical Grade (5Z,8Z,11Z,14Z)icosa-5,8,11,14-tetraenoic acid Arachidonic acid, from porcine liver, BioReagent, suitable for cell culture, >=99% (GC) 1753-EP2298767A1 BSPBio_001539 1gnj cis,cis,cis,cis-5,8,11,14-Eicosatetraenoic acid; Eicosa-5Z,8Z,11Z,14Z-tetraenoic acid 5,8,11,14-Eicosatetraenoic acid DB04557 5Z,8Z,11Z,14Z-Eicosatetraenoate HMS1989M21 789-EP2295426A1 MLS001361328 789-EP2305684A1 SC-19271 93444-49-6 YZXBAPSDXZZRGB-DOFZRALJSA-N all-cis-5,8,11,14-Eicosatetraenoate (14C)-arachidonic acid (5Z,8Z,11Z,14Z)-5,8,11,14-Eikosatetraensaeure Arachidonic acid, >95.0% (GC) 1753-EP2272832A1 BC207586 1753-EP2311453A1 CCG-214838 27YG812J1I cis-D5,8,11,14-Eicosatetraenoic acid 5,8,11,14-Icosatetraenoic Acid EINECS 208-033-4 789-EP2277848A1 HY-109590 789-EP2298735A1 NCGC00094608-02 789-EP2308848A1 Spectrum5_001910 AC-14348 arachidonate Arachidonic acid (in Tocrisolvetrade mark100) (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid Arachidonic acid, from porcine liver, >=85% (capillary GC), liquid 1753-EP2295055A2 BRD-K03070961-001-02-8 1753-EP2314587A1 CHEMBL15594 5,8,11,14-all-cis-Eicosatetraenoicmmunocytophyte D0HD9P 506-32-1 HMS1361M21 789-EP2289871A1 LMFA01030001 789-EP2305250A1 NCGC00094608-05 789-EP2311837A1 ST069383 AI3-09613 Arachidonic acid, 1.0 mg/mL in ethanol, certified reference material (all-Z)-5,8,11,14-Eicosatetraenoate Arachidonicacid 1753-EP2301922A1 C00219 1vyg cis-5,8,11,14-Eicosatetraenoic acid 5,8,11,14-Eicosatetraenoic acid, (all-Z)- DTXSID4040420 5Z,8Z,11Z,14Z-eicosatetraenoic acid HMS3402M21 789-EP2295427A1 MolPort-003-666-529 789-EP2305689A1 SCHEMBL16162 A0781 ZINC4474696 all-cis-5,8,11,14-eicosatetraenoic acid (14C)Arachidonic acid (5Z,8Z,11Z,14Z)-5,8,11,14-Icosatetraenoic acid Arachidonic acid, analytical standard 1753-EP2277848A1 BDBM22319 1753-EP2311806A2 CCRIS 6312 5,8,11,14-all-cis-Eicosatetraenoate cis-Delta(5,8,11,14)-eicosatetraenoic acid 5-cis,8-cis,11-cis,14-cis-Eicosatetraenoate FA 20:4 789-EP2277880A1 IDI1_034009 789-EP2301536A1 NCGC00094608-03 789-EP2308879A1 SR-01000838311 AC1L9H30 Arachidonic Acid Powder (5Z,8Z,11Z,14Z)-Icosatetraenoic acid Arachidonic acid, from porcine liver, >=99% (GC), liquid 1753-EP2295423A1 BRD-K03070961-001-04-4 1adl cis,cis,cis,cis-5,8,11,14-Eicosatetraenoic acid 5,8,11,14-Eicosatetraenoate D18DBC10-379C-4E78-9A50-8B791A2F4E68 506A321 HMS1791M21 789-EP2292610A1 MFCD00004417 789-EP2305682A1 NCGC00094608-06 789-EP2316835A1 UNII-27YG812J1I AKOS015950830 (5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic Acid Arachidonic Acid, 99% (all-Z)-5,8,11,14-Eicosatetraenoic acid Arachidonsaeure 1753-EP2305641A1 C20:4 cis-D5,8,11,14-Eicosatetraenoate 5,8,11,14-Eicosatetraenoic acid, labeled with carbon-14, (all-Z)- Eicosa-5Z,8Z,11Z,14Z-tetraenoic acid 5Z,8Z,11Z,14Z-icosatetraenoic acid HMS3649B05 789-EP2295432A1 NCGC00094608-01 789-EP2308839A1 SMR000857374 AB1004494 [1-14C]Arachidonic acid AN-21456 [ Show all ]
Inchi Key	YZXBAPSDXZZRGB-DOFZRALJSA-N
Inchi ID	InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-15-
PubChem CID	444899
ChEMBL	N/A
IUPHAR	N/A
BindingDB	22319
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID6317122	BindingDB

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