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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesHomo sapiens (Human)
GeneGHSR
Synonymghrelin receptor
GH-releasing peptide receptor
GHRP
GHS-R
growth hormone-releasing peptide receptor
[ Show all ]
DiseaseN/A
Length366
Amino acid sequenceMWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProtQ92847
Protein Data BankN/A
GPCR-HGmod modelQ92847
3D structure modelThis predicted structure model is from GPCR-EXP Q92847.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4616
IUPHAR246
DrugBankBE0003383

Ligand

NameCHEMBL1080939
Molecular formulaC26H23ClN4O2
IUPAC name[(2S)-4-[6-(2-chlorophenyl)pyridine-3-carbonyl]-2-methylpiperazin-1-yl]-(1H-indol-6-yl)methanone
Molecular weight458.946
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.1
Synonyms(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(6-(2-chlorophenyl)pyridin-3-yl)methanone
BDBM50312789
Inchi KeyXEHQXDOCWMOAJG-KRWDZBQOSA-N
Inchi IDInChI=1S/C26H23ClN4O2/c1-17-16-30(12-13-31(17)26(33)19-7-6-18-10-11-28-24(18)14-19)25(32)20-8-9-23(29-15-20)21-4-2-3-5-22(21)27/h2-11,14-15,17,28H,12-13,16H2,1H3/t17-/m0/s1
PubChem CID46880727
ChEMBLCHEMBL1080939
IUPHARN/A
BindingDB50312789
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5013.0 nMPMID20137933BindingDB,ChEMBL

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