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GPCR

NameFree fatty acid receptor 2
SpeciesHomo sapiens (Human)
GeneFFAR2
SynonymFFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
GPR43
[ Show all ]
DiseaseAbortion
Diabetes
Length330
Amino acid sequenceMLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProtO15552
Protein Data BankN/A
GPCR-HGmod modelO15552
3D structure modelThis predicted structure model is from GPCR-EXP O15552.
BioLiPN/A
Therapeutic Target DatabaseT28213
ChEMBLCHEMBL5493
IUPHAR226
DrugBankN/A

Ligand

Namepropionic acid
Molecular formulaC3H6O2
IUPAC namepropanoic acid
Molecular weight74.079
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP0.3
Synonyms613-EP2298747A1
11906-EP2301916A2
613-EP2301924A1
11906-EP2311799A1
613-EP2305649A1
[ Show all ]
Inchi KeyXBDQKXXYIPTUBI-UHFFFAOYSA-N
Inchi IDInChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)
PubChem CID1032
ChEMBLCHEMBL14021
IUPHAR1062
BindingDB50082199
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5012589.3 - 1000000.0 nMPMID12496283, PMID12684041, PMID12711604, PMID21220428IUPHAR
Efficacy100.0 %PMID20005104ChEMBL
IC50130000.0 nMPMID20005104BindingDB,ChEMBL

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