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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-1D adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1d
Synonym	ADRA1A Gpcr8 Adra-1 alpha1D-AR alpha1D-adrenoceptor alpha1a/d-adrenoceptor alpha1A/D alpha1A-adrenoceptor Alpha-1D adrenoreceptor Alpha-1D adrenoceptor ADRA1 Alpha-1A adrenergic receptor alpha 1D-adrenoreceptor alpha 1D-adrenoceptor adrenergic receptor delta1 Adrd1 ADRA1R RA42 [ Show all ]
Disease	N/A for non-human GPCRs
Length	561
Amino acid sequence	MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKPASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDYSNLRETDI
UniProt	P23944
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL326
IUPHAR	24
DrugBank	N/A

Ligand

Name	CHEMBL88109
Molecular formula	C25H30N6O2
IUPAC name	N,N-dimethyl-2-[4-[2-(2-pyrimidin-5-ylphenoxy)ethylamino]piperidin-1-yl]pyridine-3-carboxamide
Molecular weight	446.555
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	2.5
Synonyms	N/A
Inchi Key	WXGIPCLOTPTJPY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H30N6O2/c1-30(2)25(32)22-7-5-11-29-24(22)31-13-9-20(10-14-31)28-12-15-33-23-8-4-3-6-21(23)19-16-26-18-27-17-19/h3-8,11,16-18,20,28H,9-10,12-15H2,1-2H3
PubChem CID	44323554
ChEMBL	CHEMBL88109
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	2511.89 nM	PMID9276013	ChEMBL

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