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GLASS

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GPCR

Name	Lysophosphatidic acid receptor 2
Species	Homo sapiens (Human)
Gene	LPAR2
Synonym	endothelial differentiation gene 4, lysophosphatidic acid G-protein-coupled receptor 4 LPA receptor 2 LPA-2 Edg4 Lysophosphatidic acid receptor Edg-4 Pbx4 pre-B-cell leukemia transcription factor 4 LPA2 receptor [ Show all ]
Disease	N/A
Length	351
Amino acid sequence	MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
UniProt	Q9HBW0
Protein Data Bank	N/A
GPCR-HGmod model	Q9HBW0
3D structure model	This predicted structure model is from GPCR-EXP Q9HBW0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3724
IUPHAR	273
DrugBank	N/A

Ligand

Name	1-Oleoyl Lysophosphatidic Acid
Molecular formula	C21H41O7P
IUPAC name	[(2R)-2-hydroxy-3-phosphonooxypropyl] (Z)-octadec-9-enoate
Molecular weight	436.526
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	5.2
Synonyms	1-oleylglycerol 3-phosphate AC1NSKBQ HMS1791G08 LPA(18:1n9/0:0) Lysophosphatidic acid(18:1n9/0:0) PA(18:1(9Z)/0:0) [(2R)-2-hydroxy-3-phosphonooxypropyl] (Z)-octadec-9-enoate 18:1 LPA C21H41O7P IDI1_033876 LysoPA(18:1) Monooleylphosphatidic acid SR-01000946335 (R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-propyl ester 1-Oleoyl-sn-glycero-3-phosphate 1-oleyl-2-lyso-sn-glycerol 3-phosphatidic acid 9-Octadecenoic acid (9Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester CHEMBL117021 LPA(18:1(9Z)/0:0) Lysophosphatidic acid(18:1) NCGC00161386-03 WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-O-oleoyl-sn-glycerol 3-phosphate 1-Oleyllysophosphatidic acid BDBM50148348 HMS1989G08 LPA(18:1w9/0:0) Lysophosphatidic acid(18:1w9/0:0) PA(18:1/0:0) (2r)-2-Hydroxy-3-(Phosphonooxy)propyl (9e)-Octadec-9-Enoate 1-oleoyl-2-lyso-sn-glycerol 3-phosphatidic acid CHEBI:62837 LMGP10050008 LysoPA(18:1w9/0:0) NCGC00161386-01 SR-01000946335-1 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate 1-Oleoyl-sn-glycerol 3-phosphate 1-oleyl-sn-glycerol 3-phosphate 9-Octadecenoic acid (Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester, (R)- Epitope ID:158640 LPA(18:1/0:0) Lysophosphatidic acid(18:1/0:0) NKP ZINC8860530 1-O-oleyl-sn-glycerol 3-phosphate 1293AH BSPBio_001406 HMS3650F05 LysoPA(18:1(9Z)/0:0) MolPort-009-019-282 SCHEMBL1560791 (2R)-2-hydroxy-3-(phosphonooxy)propyl (9Z)-octadec-9-enoate 1-Oleoyl-L-.alpha.-lysophosphatidic acid 65528-98-5 LPA 18:1 lysophosphatidic acid NCGC00161386-02 UNII-PG6M3969SG component WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoric acid 1-oleoylglycerol 3-phosphate [ Show all ]
Inchi Key	WRGQSWVCFNIUNZ-GDCKJWNLSA-N
Inchi ID	InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-/t20-/m1/s1
PubChem CID	5311263
ChEMBL	CHEMBL117021
IUPHAR	N/A
BindingDB	50148348
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2.0 nM	PMID25100502	BindingDB
EC50	2.0 nM	PMID25100502	ChEMBL
EC50	6.8 nM	PMID15177455	BindingDB,ChEMBL
EC50	28.84 nM	PMID23395664	ChEMBL
EC50	29.0 nM	PMID23395664	BindingDB,ChEMBL
Emax	100.0 %	PMID15177455	ChEMBL
Intrinsic activity	1.0 -	PMID23395664	ChEMBL

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