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GPCR

Name	D(1A) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD1
Synonym	D1 receptor D1A DADR Gpcr15 dopamine D1 receptor Dopamine-1A receptor [ Show all ]
Disease	Unspecified Hypertension Pain Parkinson's disease Psychiatric disorder Psychotic disorders Schizophrenia Substance dependence Type 2 diabetes Excessive bleeding following childbirth and spontaneous or elective abortion Cocaine addiction Dementia Cognitive disorders [ Show all ]
Length	446
Amino acid sequence	MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProt	P21728
Protein Data Bank	N/A
GPCR-HGmod model	P21728
3D structure model	This predicted structure model is from GPCR-EXP P21728.
BioLiP	N/A
Therapeutic Target Database	T22118
ChEMBL	CHEMBL2056
IUPHAR	214
DrugBank	BE0000020

Ligand

Name	triprolidine
Molecular formula	C19H22N2
IUPAC name	2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine
Molecular weight	278.399
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.9
Synonyms	NCGC00024714-11 2-((E)-3-Pyrrolidin-1-yl-1-p-tolyl-propenyl)-pyridine SBI-0025383.P004 2L8T9S52QM trans-2-(3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)pyridine AB00053563_14 Triprolidine HCL ALLERFED ZINC12503099 BSPBio_000104 DSSTox_GSID_23718 IDI1_000297 Myidyl Prestwick3_000262 2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine T 6764 Tripolidina ACTAHIST Triprolidine [INN:BAN] BIDD:GT0569 CAS-486-12-4 D08648 EINECS 207-627-0 Lopac0_001130 NCGC00024714-04 (E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)pyridine 1-((E)-3-Pyridin-2-yl-3-p-tolyl-allyl)-pyrrolidinium Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, (E)- 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine hydrochloride trans-1-(2-Pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene AB00053563-02 Actifed UNII-2L8T9S52QM BRD-K11742128-003-05-1 CCRIS 7212 DB00427 HMS2089M21 MYFED NCGC00024714-07 NCI-C61450 2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)pyridine SCHEMBL4905 486-12-4 TRILITRON AC1NR02Y Triprolidine Monohydrochloride AN-45232 BSPBio_002255 CHEMBL855 DSSTox_RID_77161 KB-105517 NCGC00024714-02 Pyridine, 2-((1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl)-, hydrochloride (1:1) 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ium-1-ylprop-1-enyl]pyridine chloride Tox21_110919 550-70-9 (mono-hydrochloride) Tripolidina [INN-Spanish] Actidil Triprolidinum BIM-0025383.P001 CBEQULMOCCWAQT-WOJGMQOQSA-N D0E8CI GTPL1228 LS-1293 NCGC00024714-05 (E)-2-1-(4-METHYLPHENYL)-3-(1-PYRROLIDINYL)-1-PROPENYL-PYRIDINE Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, (E)- 2-[(E)-1-(p-tolyl)-3-pyrrolidin-1-yl-prop-1-enyl]pyridine trans-1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene AB00053563-13 Triprolidine (INN) AKOS027460758 Venen (TN) BRD-K11742128-003-15-0 CHEBI:84116 DSSTox_CID_3718 HSDB 6316 Myidil (TN) NCGC00024714-08 Prestwick2_000262 2-(3-Pyrrolidin-1-yl-1-p-tolyl-propenyl)-pyridine Spectrum5_001467 486T124 TRIPHED ACM486124 Triprolidine Monohydrochloride, Monohydrate BDBM50292411 C19H22N2 CORPHED DTXSID3023718 L000901 NCGC00024714-03 (E)-2-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)pyridine (E)-2-[3-(1-Pyrrolidinyl)-1-p-toluenepropenyl]pyridine Pyridine, 2-((1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, monohydrochloride 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine Tox21_110919_1 6138-79-0 (mono-hydrochloride, mono-hydrate) Triprolidin Actidil (TN) Triprolidinum [INN-Latin] BPBio1_000116 CCG-12422 Histafed MolPort-003-182-178 NCGC00024714-06 [ Show all ]
Inchi Key	CBEQULMOCCWAQT-WOJGMQOQSA-N
Inchi ID	InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
PubChem CID	5282443
ChEMBL	CHEMBL855
IUPHAR	1228
BindingDB	50292411
DrugBank	DB00427
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	13.0 nM	PubChem BioAssay data set	ChEMBL

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