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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Pyroglutamylated RF-amide peptide receptor
Species	Homo sapiens (Human)
Gene	QRFPR
Synonym	QRFP receptor peptide p518 receptor Orexigenic neuropeptide QRFP receptor GPR103 G-protein coupled receptor 103 G protein-coupled receptor 103 AQ27 SP9155 [ Show all ]
Disease	N/A
Length	431
Amino acid sequence	MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
UniProt	Q96P65
Protein Data Bank	N/A
GPCR-HGmod model	Q96P65
3D structure model	This predicted structure model is from GPCR-EXP Q96P65.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5852
IUPHAR	333
DrugBank	N/A

Ligand

Name	CHEMBL1802380
Molecular formula	C48H58FN11O9
IUPAC name	(2S)-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[2-(4-fluorophenyl)acetyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]pentanamide
Molecular weight	952.058
Hydrogen bond acceptor	11
Hydrogen bond donor	11
XlogP	0.8
Synonyms	BDBM50347857
Inchi Key	WMHJWVACQAWJHH-MQDBWYGVSA-N
Inchi ID	InChI=1S/C48H58FN11O9/c49-34-20-18-33(19-21-34)26-40(62)54-27-41(63)55-28-42(64)56-37(24-31-13-6-2-7-14-31)45(67)60-39(29-61)47(69)59-38(25-32-15-8-3-9-16-32)46(68)57-35(17-10-22-53-48(51)52)44(66)58-36(43(50)65)23-30-11-4-1-5-12-30/h1-9,11-16,18-21,35-39,61H,10,17,22-29H2,(H2,50,65)(H,54,62)(H,55,63)(H,56,64)(H,57,68)(H,58,66)(H,59,69)(H,60,67)(H4,51,52,53)/t35-,36-,37-,38-,39-/m0/s1
PubChem CID	53363899
ChEMBL	CHEMBL1802380
IUPHAR	N/A
BindingDB	50347857
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	830.0 nM	PMID21623631	BindingDB,ChEMBL

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