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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Rattus norvegicus (Rat)
Gene	Chrm2
Synonym	cholinergic receptor cholinergic receptor, muscarinic 2 AChR M2 Chrm-2 M2 muscarinic acetylcholine receptor M2 receptor cholinergic receptor, muscarinic 2, cardiac [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P10980
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL309
IUPHAR	14
DrugBank	N/A

Ligand

Name	Telenzepine
Molecular formula	C19H22N4O2S
IUPAC name	1-methyl-10-[2-(4-methylpiperazin-1-yl)acetyl]-5H-thieno[3,4-b][1,5]benzodiazepin-4-one
Molecular weight	370.471
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	1.7
Synonyms	SPBio_002485 Telenzepino [Spanish] 1-methyl-10-[2-(4-methylpiperazin-1-yl)acetyl]-5H-thieno[3,4-b][1,5]benzodiazepin-4-one VSWPGAIWKHPTKX-UHFFFAOYSA-N BRD-K06147391-300-04-3 CCG-205278 DSSTox_GSID_45209 L001013 NCGC00015987-04 NSC_5387 Telenzepine dihydrochloide Tocris-1122 4,9-Dihydro-3-methyl-4-((4-methyl-1-piperazinyl)acetyl)-10H-thieno(3,4-b)(1,5)benzodiazepin-10-one API0015667 BY-802 CHEMBL253978 GTPL8594 LS-177594 NCGC00015987-07 Prestwick2_000303 Telenzepine [INN] Tox21_110274_1 4,9-Dihydro-3-methyl-4beta-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one BRD-K06147391-003-01-9 CAS-80880-90-6 D0FX4J HMS3374A10 NCGC00015987-02 NCGC00025013-02 SCHEMBL49345 Spectrum3_001839 Telenzepinum 3-methyl-4-(2-(4-methylpiperazin-1-yl)acetyl)-4H-benzo[b]thieno[3,4-e][1,4]diazepin-10(9H)-one ZINC19796161 BSPBio_000266 CHEBI:92110 DSSTox_RID_80752 Lopac-T-122 NCGC00015987-05 Prestwick0_000303 Telenzepine dihydrochloride hydrate (+)-Telenzepine Tox21 110274 4,9-Dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one dihydrochloride BDBM82376 C19H22N4O2S CTK6I3128 HMS2089M03 MLS000069348 NCGC00015987-09 Prestwick3_000303 SMR000058848 Telenzepino 0990EG3K10 UNII-0990EG3K10 80880-90-6 BRD-K06147391-300-03-5 CAS_80880-90-6 DSSTox_CID_25209 KBio3_003022 NCGC00015987-03 NCGC00025013-03 Telenzepinum [Latin] 3-methyl-4-[(4-methylpiperazin-1-yl)acetyl]-4,9-dihydro-10h-thieno[3,4-b][1,5]benzodiazepin-10-one [3H](+)telenzepine AC1L1K8Q BSPBio_003517 DTXSID5045209 Lopac0_001204 NCGC00015987-06 Prestwick1_000303 Telenzepine hydrochloride (-)-Telenzepine Tox21_110274 4,9-Dihydro-3-methyl-4alpha-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one BPBio1_000294 CAS-147416-96-4 D08XDK HMS2235P06 NCGC00015987-01 NCGC00025013-01 SBI-0051171.P002 [ Show all ]
Inchi Key	VSWPGAIWKHPTKX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H22N4O2S/c1-13-18-14(12-26-13)19(25)20-15-5-3-4-6-16(15)23(18)17(24)11-22-9-7-21(2)8-10-22/h3-6,12H,7-11H2,1-2H3,(H,20,25)
PubChem CID	5387
ChEMBL	CHEMBL253978
IUPHAR	8594
BindingDB	82376
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	16.98 nM	PMID2250662	BindingDB
Ki	50.0 nM	PMID2066986	BindingDB
Ki	50.3 nM	PMID2066986	ChEMBL

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