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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	949034-59-7
Molecular formula	C6H6N2O3
IUPAC name	4,6-dihydro-1H-furo[3,4-c]pyrazole-3-carboxylic acid
Molecular weight	154.125
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	-0.7
Synonyms	2,6-dihydro-4H-Furo[3,4-c]pyrazole-3-carboxylic acid BDBM50132135 4h-furo[3,4-c]pyrazole-3-carboxylic acid,2,6-dihydro- KB-192130 1417985-33-1 AKOS023412036 4,6-Dihydro-1H-furo[3,4-c]pyrazole-3-carboxylic acid SCHEMBL14555868 1H-Furo[3,4-c]pyrazole-3-carboxylic acid, 4,6-dihydro- AKOS023610617 4,6-dihydro-2H-furo[3,4-c]pyrazole-3-carboxylic acid CHEMBL338071 ZINC27313841 [ Show all ]
Inchi Key	VBEOEILKNBIXDR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H6N2O3/c9-6(10)5-3-1-11-2-4(3)7-8-5/h1-2H2,(H,7,8)(H,9,10)
PubChem CID	44351665
ChEMBL	CHEMBL338071
IUPHAR	N/A
BindingDB	50132135
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2700.0 nM	PMID17588745	BindingDB,ChEMBL

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