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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Lysophosphatidic acid receptor 2
Species	Homo sapiens (Human)
Gene	LPAR2
Synonym	endothelial differentiation gene 4, lysophosphatidic acid G-protein-coupled receptor 4 LPA receptor 2 LPA-2 Edg4 Lysophosphatidic acid receptor Edg-4 Pbx4 pre-B-cell leukemia transcription factor 4 LPA2 receptor [ Show all ]
Disease	N/A
Length	351
Amino acid sequence	MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
UniProt	Q9HBW0
Protein Data Bank	N/A
GPCR-HGmod model	Q9HBW0
3D structure model	This predicted structure model is from GPCR-EXP Q9HBW0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3724
IUPHAR	273
DrugBank	N/A

Ligand

Name	CHEMBL485119
Molecular formula	C15H12N2O8
IUPAC name	2,6-bis[[(E)-3-carboxyprop-2-enoyl]amino]benzoic acid
Molecular weight	348.267
Hydrogen bond acceptor	8
Hydrogen bond donor	5
XlogP	-0.1
Synonyms	2,6-bis[[(E)-4-hydroxy-4-oxobut-2-enoyl]amino]benzoic acid SCHEMBL13957720 AC1NYOZI 4,4''-(2-carboxy-1,3-phenylene)bis(azanediyl)bis(4-oxobut-2-enoic acid) ZINC1679105 BDBM50271701 2,6-bis(3-carboxyacrylamido)benzoic acid NSC-47091 [ Show all ]
Inchi Key	AEFXZQBYWHGBOY-YDFGWWAZSA-N
Inchi ID	InChI=1S/C15H12N2O8/c18-10(4-6-12(20)21)16-8-2-1-3-9(14(8)15(24)25)17-11(19)5-7-13(22)23/h1-7H,(H,16,18)(H,17,19)(H,20,21)(H,22,23)(H,24,25)/b6-4+,7-5+
PubChem CID	5861754
ChEMBL	CHEMBL485119
IUPHAR	N/A
BindingDB	50271701
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	355.0 nM	PMID18467108, PMID19800804	BindingDB,ChEMBL
Imax	53.3 %	PMID18467108, PMID19800804	ChEMBL

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