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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide FF receptor 2
Species	Homo sapiens (Human)
Gene	NPFFR2
Synonym	NPFF2 receptor Neuropeptide G-protein coupled receptor GPR74 G-protein coupled receptor HLWAR77 G-protein coupled receptor 74 G protein-coupled receptor 74 F8Famide receptor NPGPR [ Show all ]
Disease	N/A
Length	522
Amino acid sequence	MNSFFGTPAASWCLLESDVSSAPDKEAGRERRALSVQQRGGPAWSGSLEWSRQSAGDRRRLGLSRQTAKSSWSRSRDRTCCCRRAWWILVPAADRARRERFIMNEKWDTNSSENWHPIWNVNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPHTGRKNQEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQLVQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI
UniProt	Q9Y5X5
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5952
IUPHAR	301
DrugBank	N/A

Ligand

Name	RF 9
Molecular formula	C26H38N6O3
IUPAC name	N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]adamantane-1-carboxamide
Molecular weight	482.629
Hydrogen bond acceptor	4
Hydrogen bond donor	5
XlogP	1.4
Synonyms	1-Adamantanecarbonyl-RF-NH2 CHEBI:140980 N(2)-(tricyclo[3.3.1.1(3,7)]decan-1-ylcarbonyl)-L-arginyl-L-phenylalaninamide 876310-60-0 CS-7903 RF9 B7463 HY-107382 NCGC00485847-01 Adamantane-1-carboxylic acid [(S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-4-guanidino-butyl]-amide D08UWO SCHEMBL18041259 1-adamantanecarbonyl-Arg-Phe-NH2 BDBM50336912 MolPort-023-276-894 CHEMBL1672380 AKOS024457741 GTPL1486 ZINC43102258 [ Show all ]
Inchi Key	UMKHUSRDQFQHAK-RNJMTYCLSA-N
Inchi ID	InChI=1S/C26H38N6O3/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t17?,18?,19?,20-,21-,26?/m0/s1
PubChem CID	53320361
ChEMBL	CHEMBL1672380
IUPHAR	1486
BindingDB	50336912
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	379.0 nM	PMID22708927	BindingDB,ChEMBL
EC50	472.0 nM	PMID22708927	ChEMBL
Emax	75.0 %	PMID22708927	ChEMBL
Inhibition	40.0 %	PMID23131340	ChEMBL
Inhibition	85.0 %	PMID23131340	ChEMBL
Ki	43.0 nM	PMID23131340	BindingDB,ChEMBL
Ki	79.4328 nM	PMID16407169	IUPHAR

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