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GPCR

Name	P2Y purinoceptor 11
Species	Homo sapiens (Human)
Gene	P2RY11
Synonym	P2Y11 P2Y11 receptor purinergic receptor P2Y, G-protein coupled, 11
Disease	N/A
Length	374
Amino acid sequence	MAANVSGAKSCPANFLAAADDKLSGFQGDFLWPILVVEFLVAVASNGLALYRFSIRKQRPWHPAVVFSVQLAVSDLLCALTLPPLAAYLYPPKHWRYGEAACRLERFLFTCNLLGSVIFITCISLNRYLGIVHPFFARSHLRPKHAWAVSAAGWVLAALLAMPTLSFSHLKRPQQGAGNCSVARPEACIKCLGTADHGLAAYRAYSLVLAGLGCGLPLLLTLAAYGALGRAVLRSPGMTVAEKLRVAALVASGVALYASSYVPYHIMRVLNVDARRRWSTRCPSFADIAQATAALELGPYVGYQVMRGLMPLAFCVHPLLYMAAVPSLGCCCRHCPGYRDSWNPEDAKSTGQALPLNATAAPKPSEPQSRELSQ
UniProt	Q96G91
Protein Data Bank	N/A
GPCR-HGmod model	Q96G91
3D structure model	This predicted structure model is from GPCR-EXP Q96G91.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4867
IUPHAR	327
DrugBank	BE0005499

Ligand

Name	dATP
Molecular formula	C10H16N5O12P3
IUPAC name	[[(2R,3S,5R)-5-(6-aminopurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular weight	491.182
Hydrogen bond acceptor	16
Hydrogen bond donor	6
XlogP	-4.4
Synonyms	SUYVUBYJARFZHO-RRKCRQDMSA-N 2'-deoxyadenosine 5'-triphosphate 67460-17-7 Adenosine, 2'-deoxy-, 5'-triphosphate (6CI,7CI) BC631334 D0D8CZ deoxy[ 3h]adenosine 5'-triphosphate [(2R,3S,5R)-5-(6-aminopurin-9-yl)-3-hydroxyoxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate 2''-deoxyadenosine 5''-(tetrahydrogen triphosphate) 2'-Deoxyadenosine-5'-triphosphate, 100MM Solution AC1L271X AJ-57365 C00131 deoxy-ATP FT-0633915 (((2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl)triphosphoric acid 2'-Deoxy-ATP 5'-DATP ADENOSINE, 2'-DEOXY-, 5'-(TETRAHYDROGEN TRIPHOSPHATE) AN-8231 CHEMBL335538 Deoxyadenosine triphosphate LS-15126 UNII-K8KCC8SH6N 1927-31-7 2'-deoxyadenosine triphosphate 9H-purin-6-amine, 9-[2-deoxy-5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-beta-D-erythro-pentofuranosyl]- Adenosine, 5'-(tetrahydrogen triphosphate), 2'-deoxy- BDBM50118233 EINECS 217-662-3 [[(2R,3S,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate 2'-Datp 2'-Deoxyformycin-5'-triphosphate Adenosine 5'-(tetrahydrogen triphosphate), 2'-deoxy- AK-54718 CHEBI:16284 deoxy-ATP, 2'-deoxyadenosine triphosphate, Deoxyadenosine 5'-triphosphate GTPL1760 SCHEMBL78250 ((2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate 2'-Deoxyadenosine 5'-(tetrahydrogen triphosphate) Adenosine, 2'-deoxy-, 5'-(tetrahydrogen triphosphate) (8CI) ATP,2'-deoxy D-erythro-pentitol, 1-C-(7-amino-1H-pyrazolo(4,3-d)pyrimidin-3-yl)-1,4-anhydro-2-deoxy-, 5-(tetrahydrogen triphosphate), (R)- deoxyadenosine-triphosphate ZINC8215662 1h7a 2'-deoxyadenosine-5'-triphosphate AC-8231 Adenosine, 5'-(tetrahydrogen triphosphate), 2'-deoxy- (9CI) BRN 0071964 DB03222 Epitope ID:149167 [[(2R,3S,5R)-5-(6-aminopurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate 2'-Deoxy-5'-ATP 4-26-00-03593 (Beilstein Handbook Reference) Adenosine 5'-(tetrahydrogen triphosphate), 2'-deoxy- (9CI) AKOS022179909 Deoxyadenosine 5'-triphosphate K8KCC8SH6N [ Show all ]
Inchi Key	SUYVUBYJARFZHO-RRKCRQDMSA-N
Inchi ID	InChI=1S/C10H16N5O12P3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19)/t5-,6+,7+/m0/s1
PubChem CID	15993
ChEMBL	CHEMBL335538
IUPHAR	1760
BindingDB	50118233
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

Parameter	Value	Reference	Database source
EC50	9000.0 nM	PMID12213051	BindingDB,ChEMBL
EC50	10000.0 - 15848.9 nM	PMID10578132	IUPHAR

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