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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Cannabinoid receptor 1
Species	Rattus norvegicus (Rat)
Gene	Cnr1
Synonym	SKR6R Neuronal cannabinoid receptor Central cannabinoid receptor CB1R CB1 receptor CB1 CB-R Cann7 Cann6 Brain-type cannabinoid receptor THC receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	473
Amino acid sequence	MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
UniProt	P20272
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3571
IUPHAR	56
DrugBank	N/A

Ligand

Name	methanandamide
Molecular formula	C23H39NO2
IUPAC name	(5Z,8Z,11Z,14Z)-N-(1-hydroxypropan-2-yl)icosa-5,8,11,14-tetraenamide
Molecular weight	361.57
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	5.8
Synonyms	Arachidonyl-1'-hydroxy-2'-propylamide SCHEMBL4236530 (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid (2-hydroxy-1-methyl-ethyl)-amide CHEMBL55802 150314-39-9 AC1O5PHK PDSP1_000246 BDBM50038644 (5Z,8Z,11Z,14Z)-N-(1-hydroxypropan-2-yl)icosa-5,8,11,14-tetraenamide Icosa-5,8,11,14-tetraenoic acid(2-hydroxy-1-methyl-ethyl)-amide (0610) 5,8,11,14-Eicosatetraenamide, N-(2-hydroxy-1-methylethyl)-, (all-Z)-(+-)- AM356 PDSP2_000245 (R)-methanandamide [ Show all ]
Inchi Key	SQKRUBZPTNJQEM-ZKWNWVNESA-N
Inchi ID	InChI=1S/C23H39NO2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23(26)24-22(2)21-25/h7-8,10-11,13-14,16-17,22,25H,3-6,9,12,15,18-21H2,1-2H3,(H,24,26)/b8-7-,11-10-,14-13-,17-16-
PubChem CID	6438332
ChEMBL	CHEMBL55802
IUPHAR	N/A
BindingDB	50038644
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	150.0 nM	PMID10991998	BindingDB
Ki	155.0 nM	PMID10991998	BindingDB
Ki	240.0 nM	PMID10991998	BindingDB
Ki	330.0 nM	PMID10991998	BindingDB
Ki	630.0 nM	PMID10991998	BindingDB
Ki	1000.0 nM	PMID10991998	BindingDB
Ki	1100.0 nM	PMID10991998	BindingDB

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