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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Pyroglutamylated RF-amide peptide receptor
Species	Homo sapiens (Human)
Gene	QRFPR
Synonym	QRFP receptor peptide p518 receptor Orexigenic neuropeptide QRFP receptor GPR103 G-protein coupled receptor 103 G protein-coupled receptor 103 AQ27 SP9155 [ Show all ]
Disease	N/A
Length	431
Amino acid sequence	MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
UniProt	Q96P65
Protein Data Bank	N/A
GPCR-HGmod model	Q96P65
3D structure model	This predicted structure model is from GPCR-EXP Q96P65.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5852
IUPHAR	333
DrugBank	N/A

Ligand

Name	CHEMBL2170390
Molecular formula	C40H54N12O8
IUPAC name	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[2-(2-aminoacetyl)hydrazinyl]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide
Molecular weight	830.948
Hydrogen bond acceptor	11
Hydrogen bond donor	12
XlogP	-1.4
Synonyms	BDBM50396420
Inchi Key	SMDXCXGYILFFLE-XDIGFQIYSA-N
Inchi ID	InChI=1S/C40H54N12O8/c41-22-33(54)52-46-23-34(55)47-30(20-26-13-6-2-7-14-26)37(58)51-32(24-53)39(60)50-31(21-27-15-8-3-9-16-27)38(59)48-28(17-10-18-45-40(43)44)36(57)49-29(35(42)56)19-25-11-4-1-5-12-25/h1-9,11-16,28-32,46,53H,10,17-24,41H2,(H2,42,56)(H,47,55)(H,48,59)(H,49,57)(H,50,60)(H,51,58)(H,52,54)(H4,43,44,45)/t28-,29-,30-,31-,32-/m0/s1
PubChem CID	71456973
ChEMBL	CHEMBL2170390
IUPHAR	N/A
BindingDB	50396420
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	136.0 nM	PMID22800498	BindingDB,ChEMBL
IC50	2987.0 nM	PMID22800498	BindingDB,ChEMBL

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