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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	SMR000155256
Molecular formula	C19H17ClN4O2S
IUPAC name	ethyl (2Z)-2-(2-anilino-1,3-thiazol-4-yl)-2-[(4-chlorophenyl)hydrazinylidene]acetate
Molecular weight	400.881
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	6.6
Synonyms	AC1O34CO ethyl 2-[(4-chlorophenyl)hydrazinylidene]-2-(2-phenylazanyl-1,3-thiazol-4-yl)ethanoate 2-(2-anilino-4-thiazolyl)-2-[(4-chlorophenyl)hydrazinylidene]acetic acid ethyl ester ethyl (2Z)-2-(2-anilino-1,3-thiazol-4-yl)-2-[(4-chlorophenyl)hydrazinylidene]acetate AKOS001038599 MLS000535935 CHEMBL3199132 2-(2-anilinothiazol-4-yl)-2-[(4-chlorophenyl)hydrazono]acetic acid ethyl ester ethyl 2-(2-anilino-1,3-thiazol-4-yl)-2-[(4-chlorophenyl)hydrazinylidene]acetate BDBM57241 cid_5101936 [ Show all ]
Inchi Key	AAMBFOICAXXPQH-ULJHMMPZSA-N
Inchi ID	InChI=1S/C19H17ClN4O2S/c1-2-26-18(25)17(24-23-15-10-8-13(20)9-11-15)16-12-27-19(22-16)21-14-6-4-3-5-7-14/h3-12,23H,2H2,1H3,(H,21,22)/b24-17-
PubChem CID	6270682
ChEMBL	CHEMBL3199132
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Potency	12589.3 nM	PubChem BioAssay data set	ChEMBL

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