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GPCR

NameThromboxane A2 receptor
SpeciesMus musculus (Mouse)
GeneTbxa2r
SynonymProstanoid TP receptor
TP receptor
TXA2-R
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMWPNGTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAIVASQHAALLDWRATDPSCRLCYFMGVAMVFFGLCPLLLGAAMASERFVGITRPFSRPTATSRRAWATVGLVWVAAGALGLLPLLGLGRYSVQYPGSWCFLTLGTQRGDVVFGLIFALLGSASVGLSLLLNTVSVATLCRVYHTREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFIMQTLLQTPPVMSFSGQLLRATEHQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFSSQLQAVSLRRPPAQAMLSGP
UniProtP30987
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1795181
IUPHAR346
DrugBankN/A

Ligand

NameCHEMBL2315049
Molecular formulaC24H23Cl2FN2O2
IUPAC name6-[[5-chloro-2-[(4-chloro-2-fluorophenyl)methoxy]phenyl]methyl]-N-(2-methylpropyl)pyridine-2-carboxamide
Molecular weight461.358
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP6.6
SynonymsBDBM50424390
Inchi KeySIDBKCIQXCEIJS-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H23Cl2FN2O2/c1-15(2)13-28-24(30)22-5-3-4-20(29-22)11-17-10-18(25)8-9-23(17)31-14-16-6-7-19(26)12-21(16)27/h3-10,12,15H,11,13-14H2,1-2H3,(H,28,30)
PubChem CID71519330
ChEMBLCHEMBL2315049
IUPHARN/A
BindingDB50424390
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki<1000.0 nMPMID23218714ChEMBL

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