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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Pyroglutamylated RF-amide peptide receptor
Species	Homo sapiens (Human)
Gene	QRFPR
Synonym	QRFP receptor peptide p518 receptor Orexigenic neuropeptide QRFP receptor GPR103 G-protein coupled receptor 103 G protein-coupled receptor 103 AQ27 SP9155 [ Show all ]
Disease	N/A
Length	431
Amino acid sequence	MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
UniProt	Q96P65
Protein Data Bank	N/A
GPCR-HGmod model	Q96P65
3D structure model	This predicted structure model is from GPCR-EXP Q96P65.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5852
IUPHAR	333
DrugBank	N/A

Ligand

Name	CHEMBL1802372
Molecular formula	C41H55N11O8
IUPAC name	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide
Molecular weight	829.96
Hydrogen bond acceptor	10
Hydrogen bond donor	11
XlogP	-0.8
Synonyms	BDBM50347859
Inchi Key	RVNVTUCFXUQQDJ-ZTTXAYQISA-N
Inchi ID	InChI=1S/C41H55N11O8/c42-24-34(54)47-25-35(55)48-32(22-27-13-6-2-7-14-27)39(59)50-30(18-20-53)38(58)52-33(23-28-15-8-3-9-16-28)40(60)49-29(17-10-19-46-41(44)45)37(57)51-31(36(43)56)21-26-11-4-1-5-12-26/h1-9,11-16,29-33,53H,10,17-25,42H2,(H2,43,56)(H,47,54)(H,48,55)(H,49,60)(H,50,59)(H,51,57)(H,52,58)(H4,44,45,46)/t29-,30-,31-,32-,33-/m0/s1
PubChem CID	53363627
ChEMBL	CHEMBL1802372
IUPHAR	N/A
BindingDB	50347859
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	374.0 nM	PMID21623631	BindingDB,ChEMBL

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