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GPCR

Name	Cysteinyl leukotriene receptor 2
Species	Homo sapiens (Human)
Gene	CYSLTR2
Synonym	CysLTR2 CysLT2 receptor LTC4 HPN321 hGPCR21 HG57 G-protein coupled receptor HG57 CYSLT2R G-protein coupled receptor GPCR21 [ Show all ]
Disease	Unspecified Asthma
Length	346
Amino acid sequence	MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
UniProt	Q9NS75
Protein Data Bank	N/A
GPCR-HGmod model	Q9NS75
3D structure model	This predicted structure model is from GPCR-EXP Q9NS75.
BioLiP	N/A
Therapeutic Target Database	T74238
ChEMBL	CHEMBL4330
IUPHAR	270
DrugBank	BE0000099

Ligand

Name	NEDOCROMIL
Molecular formula	C19H17NO7
IUPAC name	9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylic acid
Molecular weight	371.345
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	2.2
Synonyms	9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano(3,2-g)quinoline-2,8-dicarboxylic acid AKOS016014051 C19H17NO7 D06FVX FPL 59002 LS-176726 Nedocromil, >=98% (HPLC) SCHEMBL4611 Tox21_113148_1 69049-73-6 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid AC-30178 AX8144084 CHEBI:7492 DSSTox_CID_3356 FT-0630782 NCGC00182073-03 Nedocromilo ST24045863 049N736 Z-3186 9-ethyl-4,6-dioxo-10-propylpyrano[5,6-g]quinoline-2,8-dicarboxylic acid ACMC-20p1ds C-21152 CTK9A5792 DTXSID7023356 KB-79344 Nedocromil [USAN:BAN:INN] Nedocromilum [Latin] Tildade (TN) 4CA-0899 69049-74-7 (di-hydrochloride salt) 9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid AN-37979 CAS-69049-73-6 FPL-59002 MolPort-006-167-614 Nedocromil, Calcium Salt (1:1) SR-01000944506 UNII-0B535E0BN0 9-ethyl-4,6-dioxo-10-propyl-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid AC1L18TT BCP22724 CHEMBL746 DSSTox_GSID_23356 GTPL7607 Nedocromilo [Spanish] Tilade 0B535E0BN0 ZINC3782807 9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano(3,2-g)chinolin-2,8-dicarbonsaeure AJ-45597 C07255 D05129 EX-A098 L001326 Nedocromil [USAN:INN:BAN] Rapitil Tox21_113148 4H-Pyrano(3,2-g)quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl- 9-ethyl-4,6-dioxo-10-propyl-4H,6H,9H-chromeno[7,6-b]pyridine-2,8-dicarboxylic acid AB0032771 API0006233 CC-32668 DB00716 FPL59002 NCGC00182073-02 Nedocromil, Disodium Salt SR-01000944506-1 X6180 9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylic acid AC1Q6AI2 BIDD:GT0716 CS-2323 DSSTox_RID_76990 HY-13448 Nedocromil (USAN/INN) Nedocromilum Tilarin 101626-68-0 (calcium salt (1:1)) [ Show all ]
Inchi Key	RQTOOFIXOKYGAN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26)
PubChem CID	50294
ChEMBL	N/A
IUPHAR	N/A
BindingDB	N/A
DrugBank	DB00716
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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