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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Oxoeicosanoid receptor 1
Species	Homo sapiens (Human)
Gene	OXER1
Synonym	R527 oxoeicosanoid (OXE) receptor 1 OXE receptor hGPCR48 GPR170 G-protein coupled receptor TG1019 G-protein coupled receptor R527 G-protein coupled receptor 170 5-oxo-ETE receptor 5-oxo-ETE G-protein coupled receptor TG1019 [ Show all ]
Disease	N/A
Length	423
Amino acid sequence	MLCHRGGQLIVPIIPLCPEHSCRGRRLQNLLSGPWPKQPMELHNLSSPSPSLSSSVLPPSFSPSPSSAPSAFTTVGGSSGGPCHPTSSSLVSAFLAPILALEFVLGLVGNSLALFIFCIHTRPWTSNTVFLVSLVAADFLLISNLPLRVDYYLLHETWRFGAAACKVNLFMLSTNRTASVVFLTAIALNRYLKVVQPHHVLSRASVGAAARVAGGLWVGILLLNGHLLLSTFSGPSCLSYRVGTKPSASLRWHQALYLLEFFLPLALILFAIVSIGLTIRNRGLGGQAGPQRAMRVLAMVVAVYTICFLPSIIFGMASMVAFWLSACRSLDLCTQLFHGSLAFTYLNSVLDPVLYCFSSPNFLHQSRALLGLTRGRQGPVSDESSYQPSRQWRYREASRKAEAIGKLKVQGEVSLEKEGSSQG
UniProt	Q8TDS5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1628461
IUPHAR	271
DrugBank	N/A

Ligand

Name	5-Oxo-15-hete
Molecular formula	C20H30O4
IUPAC name	(6E,8Z,11Z,13E,15S)-15-hydroxy-5-oxoicosa-6,8,11,13-tetraenoic acid
Molecular weight	334.456
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.9
Synonyms	6,8,11,13-Eicosatetraenoic acid, 15-hydroxy-5-oxo-, (S-(E,E,Z,Z))- GTPL6167 BDBM50338299 142828-12-4 CHEMBL1682258 5-oxo-15-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoic acid (6E,8Z,11Z,13E,15S)-15-hydroxy-5-oxoicosa-6,8,11,13-tetraenoic acid CHEBI:137746 15-hydroxy-5-oxo-eicosa-6(E),8(Z),11(Z),13(E)tetraenoic acid D0JH4U 5-Oxo-15-hydroxy-6,8,11,13-eicosatetraenoic acid AC1O5QAA (6E,8Z,11Z,13E,15S)-15-hydroxy-5-oxoicosatetraenoic acid [ Show all ]
Inchi Key	RIUDRKHGFDAKPO-WWWYWCMOSA-N
Inchi ID	InChI=1S/C20H30O4/c1-2-3-9-13-18(21)14-10-7-5-4-6-8-11-15-19(22)16-12-17-20(23)24/h5-8,10-11,14-15,18,21H,2-4,9,12-13,16-17H2,1H3,(H,23,24)/b7-5-,8-6-,14-10+,15-11+/t18-/m0/s1
PubChem CID	6438757
ChEMBL	CHEMBL1682258
IUPHAR	6167
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	20.0 nM	PMID7803484, PMID8387490, PMID7797484, PMID8598482	IUPHAR
EC50	56.0 nM	PMID21316960	ChEMBL

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